Sinai Cedars Intellectual Property Co



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FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

INITIAL DECLARATION OF EFFECTIVE OWNERSHIP OF SECURITIES

Filed in accordance with Section 16 (a) of the Securities Exchange Act of 1934
or Section 30 (h) of the Investment Companies Act 1940

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1. Name and address of the declaring person
*



(Street)
2. Date of the event requiring notification (month / day / year)
06/25/2021

3. Issuer name
and
Ticker or trade symbol


Prometheus Biosciences, Inc.
[
RXDX
]
4. Relationship between the declaring person (s) and the issuer

(Check all that apply)
Director X 10% Owner
Officer (give title below) Other (specify below)
5. In case of modification, date of deposit of the original (month / day / year)
6. Individual or spouse / group deposit (Check the applicable line)
X Form filed by a declaring person
Form submitted by more than one declarant
Table I – Non-derivative securities beneficially owned
1. Security Title (Instr. 4) 2. Amount of securities beneficially owned (Instr. 4) 3. Form of ownership: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of indirect beneficial ownership (Instr. 5)

Ordinary actions

5,008.508

I

See footnote

(1)

Table II – Derivative securities beneficially owned
(for example, put options, call options, warrants, options, convertible securities)
1. Title of the derivative title (Instr. 4) 2. Exercise date and expiry date (month / day / year) 3. Title and amount of the securities underlying the derivative security (Instr. 4) 4. Conversion or exercise price of the derivative security 5. Form of ownership: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of indirect beneficial ownership (Instr. 5)
Exercise date Expiration date Title Amount or number of shares
Explanation of answers:
/ s / Timothy K. Andrews, actual lawyer 06/25/2021
** Signature of the declaring person Dated
Reminder: Report on a separate line for each category of securities held directly or indirectly.
* If the form is submitted by more than one declarant,
see

Instruction 4 (b) (v).

** Intentional inaccuracies or factual omissions constitute federal criminal offenses
See

18 USC 1001 and 15 USC 78ff (a).

Note: Submit three copies of this form, one of which must be signed manually. If there is not enough space,
see

Instruction 6 for the procedure.

People who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.
POWER OF ATTORNEY

        Know all by these presents, that the undersigned hereby constitutes and
appoints each of the Chief Financial Officer, who is currently Keith W.
Marshall, Ph.D. and the General Counsel, who is currently Timothy K. Andrews,
and their respective successors, signing singly, the undersigned's true and
lawful attorney-in-fact to:

        (1)  prepare, execute in the undersigned's name and on the undersigned's
behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a
Form ID, including amendments thereto, and any other documents necessary or
appropriate to obtain codes and passwords enabling the undersigned to make
electronic filings with the SEC of reports required by Section 16(a) of the
Securities Exchange Act of 1934 or any rule or regulation of the SEC;

        (2)  execute for and on behalf of the undersigned, in the undersigned's
capacity as an officer and/or director of Prometheus Biosciences, Inc., a
Delaware corporation (the "Company") and/or beneficial owner of more than 10% of
the Company's capital stock, Forms 3, 4, and 5 and any amendments thereto in
accordance with Section 16(a) of the Securities Exchange Act of 1934 and the
rules thereunder;

        (3)  do and perform any and all acts for and on behalf of the
undersigned which may be necessary or desirable to complete and execute any such
Form 3, 4, or 5, complete and execute any amendment or amendments thereto, and
timely file such form with the SEC and any stock exchange or similar authority;
and

        (4)  take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of the
undersigned pursuant to this Power of Attorney shall be in such form and shall
contain such terms and conditions as such attorney-in-fact may approve in such
attorney-in-fact's discretion.

	The undersigned hereby grants to each such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney-in-fact, or such
attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be
done by virtue of this Power of Attorney and the rights and powers herein
granted. The undersigned acknowledges that the foregoing attorneys-in-fact, in
serving in such capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Securities Exchange Act of 1934.

	The undersigned agrees that each such attorney-in-fact herein may rely entirely
on information furnished orally or in writing by the undersigned to such
attorney-in-fact.  The undersigned also agrees to indemnify and hold harmless
the Company and each such attorney-in-fact against an losses, claims, damages or
liabilities (or actions in these reports) that arise out of or are based upon
any untrue statements or omission of necessary facts in the information provided
by the undersigned to such attorney-in-fact for purposes of executing,
acknowledging, delivering or filing Forms 3, 4 or 5 (including amendments
thereto) or Form ID and agrees to reimburse the Company and such
attorney-in-fact for any legal or other expenses reasonably incurred in
connection with investigating or defending against any such loss, claim, damage,
liability or action.

	This Power of Attorney supersedes any power of attorney previously executed by
the undersigned regarding the purposes outlined in the first paragraph hereof
("Prior Powers of Attorney"), and the authority of the attorney-in-fact named in
any Prior Powers of Attorney is hereby revoked.

	This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

	IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of this 25th day of June, 2021.

                                                           CEDARS SINAI
INTELLECTUAL
                                                           PROPERTY COMPANY

                                                           By: /s/ James D.
Laur
                                                           Name: James D. Laur
                                                           Title: President


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